![]() This review discusses these relationships in the context of obstetric management. A number of associations between hepatic dysfunction and pregnancy exist. Isolated hepatic disease rarely occurs during pregnancy. Therapy with penicillamine, trientine, prednisone or azathioprine can be safely continued during pregnancy. ![]() Treatment involves prompt delivery, whereupon the liver disease quickly reverses. These rare diseases result in increased maternal and fetal mortality. Preeclampsia is associated with HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome, acute fatty liver of pregnancy, and hepatic infarction and rupture. ![]() Women with chronic liver disease or cirrhosis exhibit a higher risk of fetal loss during pregnancy. Cholelithiasis occurs in 6 percent of pregnancies complications can safely be treated with surgery. Chronic hepatitis B or C infections may be transmitted to neonates however, hepatitis B virus transmission is effectively prevented with perinatal hepatitis B vaccination and prophylaxis with hepatitis B immune globulin. The course of acute hepatitis is unaffected by pregnancy, except in patients with hepatitis E and disseminated herpes simplex infections, in which maternal and fetal mortality rates are significantly increased. Acute viral hepatitis is the most common cause of jaundice in pregnancy.
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